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		<title>Vaccine Makers Struggle to Speed Output</title>
		<link>http://medcall.wordpress.com/2009/11/25/vaccine-makers-struggle-to-speed-output/</link>
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		<pubDate>Wed, 25 Nov 2009 13:53:06 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[H1N1 Update]]></category>

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		<description><![CDATA[Cell-Culture Technology Hastens the Process, but Slow-Growing Virus Remains a Problem, and U.S. Production Is Years Away A new Novartis AG vaccine plant in North Carolina is supposed to boost the U.S.&#8217;s ability to fight pandemics like the current swine-flu virus. But despite a ribbon-cutting Tuesday, it won&#8217;t be pumping out flu shots for at [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=32&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<h2>Cell-Culture Technology Hastens the Process, but Slow-Growing Virus Remains a Problem, and U.S. Production Is Years Away</h2>
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<p>A new <a href="/public/quotes/main.html?type=djn&amp;symbol=nvs">Novartis</a> AG vaccine plant in North Carolina is supposed to boost the U.S.&#8217;s ability to fight pandemics like the current swine-flu virus. But despite a ribbon-cutting Tuesday, it won&#8217;t be pumping out flu shots for at least another two years.</p>
<p> Nor will the plant&#8217;s cutting-edge technology do much to solve one of the biggest problems vaccine makers have faced in churning out this year&#8217;s swine-flu vaccine: a slow-growing virus. High-speed techniques that bypass the lengthy and onerous process of incubating viruses to make vaccine are years away.</p>
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<p><a><img src="http://s.wsj.net/public/resources/images/NA-BC257_VACCIN_D_20091124185944.jpg" border="0" alt="Novartis" hspace="0" width="262" height="174" /></a><cite>Reuters</cite>Novartis employees clean equipment at the Novartis flu vaccine facility in Holly Springs, N.C., on Tuesday.</p>
<p>After more than five years and about $2 billion in government spending, the U.S. is still struggling to modernize and speed up production of vaccinations against deadly pandemics like swine flu. The system is undermined by a lack of manufacturing plants and by decades-old technology that takes six to nine months to make flu vaccine.</p>
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<p> The new Novartis plant, heavily financed by the U.S. government, represents one of the biggest steps in 60 years toward modernizing flu-vaccine manufacturing in the U.S. It uses new technology to grow flu viruses in vats of cells derived from dog kidneys, and uses these viruses to make vaccine. The decades-old process involves growing the virus in chicken eggs.</p>
<p> Novartis says the new approach could shave four to six weeks off the time needed to make each shot. The plant has other advantages: If a deadly avian-flu virus hit, it could kill scores of chickens and endanger the supply of eggs needed to make vaccine the old-fashioned way. Cell-culture technology removes that risk.</p>
<p> Novartis&#8217;s new plant is just one element of a bigger modernization strategy that will take years to unfold. It has taken the Swiss pharmaceutical giant more than three years to build the plant and fine-tune the technology. And the company must carry out more tests on its equipment and vaccine before it can start mass producing the shots in the U.S., even though it already has a cell-culture factory in Germany.</p>
<p> Even when the new Novartis plant is up and running, flu viruses that grow slowly in eggs, as does the current H1N1 virus, may also grow slowly in cells, meaning production may not be much faster, scientists warn.</p>
<p> Cell-culture technology &#8220;is not the end game for us,&#8221; said Anthony Fauci, director of the U.S. government&#8217;s National Institute of Allergy and Infectious Diseases. His institute is spending $262 million this year on influenza research, including research on a new generation of vaccines that can be made without having to grow a virus.</p>
<p> Protein Sciences Corp., of Meriden, Conn., received a $35 million contract from the Department of Health and Human Services in June to develop a next-generation flu vaccine that doesn&#8217;t depend on growing the virus, but inserts genetic material from a flu virus into another virus that infects insect cells. The infected insect cells produce proteins that are then used to create a vaccine for humans. Such a shot is &#8220;a year or two [away] at the most,&#8221; Dr. Fauci said. A Food and Drug Administration advisory panel narrowly voted last week against approval of the vaccine, asking for more studies.</p>
<p> The government began investing heavily in flu vaccine after the outbreak of avian flu in 2003, and then a shortage of seasonal-flu vaccine in 2004 when a large manufacturer suffered a contamination problem. HHS has put $1.56 billion into cell-based projects like the new Novartis plant.</p>
<p> But when the new H1N1 virus emerged in April, none of those technologies had yet been licensed. The government had no choice but to turn to its slow, but tried-and-true egg-based system. Then, the new H1N1 virus proved uncooperative, growing slowly in the eggs and yielding only a quarter to a third of the antigen—the main ingredient in vaccine—that manufacturers had been expecting.</p>
<p> The slow pace of modernization underscores a deeper, fundamental problem with the U.S. market for flu vaccines: uncertain demand and slim profit margins. The government is trying to build a pandemic vaccine manufacturing system on the back of a fickle market for seasonal-flu vaccine.</p>
<p> The majority of Americans routinely ignore public health officials&#8217; pleas to get an annual flu shot.</p>
<p> An oversupply of flu vaccine on the U.S. market in the past three years has pushed prices down 30% to 40%, &#8220;creating a strong disincentive for manufacturers to maximize or even maintain current production capacity for the U.S. market,&#8221; Vas Narasimhan, president of Novartis Vaccines USA, said in written testimony submitted for a congressional hearing last week.</p>
<p>It isn&#8217;t clear how many benefits cell-culture technology will offer. A spokeswoman for Illinois-based Baxter International Inc. said the company&#8217;s cell-culture plant in the Czech Republic—one of the first large-scale cell-culture facilities—initially experienced the same difficulty growing the H1N1 virus that egg-based plants did. Like other drug makers, Baxter managed to improve the yield, she said, though she declined to say by how much. Baxter is supplying 80 million doses of H1N1 vaccine to countries including Austria, the U.K., Ireland, Germany and France. Its flu vaccine isn&#8217;t licensed for sale in the U.S.</p>
<p> Other companies have had mixed results with cells. GlaxoSmithKline PLC of the U.K. received a $274 million HHS contract in 2007 to develop cell-culture vaccine and to build manufacturing capacity for it, but in an interview in September, the head of the company&#8217;s vaccine business said the technology is about a decade away from being &#8220;mature&#8221; enough for use. &#8220;GSK will be in cell-culture technology perhaps in ten years, but not today,&#8221; Jean Stephenne, the Glaxo official, said.</p>
<p> France&#8217;s Sanofi-Aventis, the world&#8217;s largest flu-vaccine maker, has also cast doubt on the immediate usefulness of cell-culture technology. In an interview in April, Sanofi&#8217;s chief executive said the sticking point was designing the right kind of cells. &#8220;We just haven&#8217;t actually found the right cell lines that do what we need them to do,&#8221; he said.&#8221;We&#8217;re still several years away from cell-based flu vaccines,&#8221; he said.</p>
<p> HHS gave Sanofi a $97 million grant in 2005 to carry out work in the area. A Sanofi spokeswoman said Tuesday that the company did develop a cell-based flu vaccine, but found that it provided only a &#8220;modest&#8221; reduction in production time and would be &#8220;considerably&#8221; more expensive to produce.</p>
<p> The &#8220;ultimate end game&#8221; is a universal flu vaccine that would protect people against all flu strains by targeting a component of the influenza virus that remains constant from season to season, said Dr. Fauci. That would eliminate the need for a flu shot every year. Novartis and other companies are at an early stage of researching such a vaccine, but such a shot is at least 10 years away, he said.</p>
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		<title>Mobile apps help people track H1N1, prevent flu</title>
		<link>http://medcall.wordpress.com/2009/11/25/mobile-apps-help-people-track-h1n1-prevent-flu/</link>
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		<pubDate>Wed, 25 Nov 2009 13:50:24 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[New Technologies in Medicine]]></category>

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		<description><![CDATA[Rumors of a disease outbreak a century ago probably would have left the general populace feeling frightened, wondering whether their town would be the next to be hit.Now the well but worried can download a flu-tracking application and find out where in their state an H1N1 outbreak has occurred and learn the best ways to [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=30&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>Rumors of a disease outbreak a century ago probably would have left the general populace feeling frightened, wondering whether their town would be the next to be hit.Now the well but worried can download a flu-tracking application and find out where in their state an H1N1 outbreak has occurred and learn the best ways to avoid it. The also can learn when vaccines will be available nearby and get news on and how some of the afflicted are doing.</p>
<p> <strong>H1N1: </strong><a href="http://www.usatoday.com/news/health/2009-11-24-glaxo-flu-vaccine-pull_N.htm" target="_blank">GlaxoSmithKline pulls vaccine in Canada</a><strong>SWINE FLU CENTRAL: </strong><a href="http://specials.usatoday.com/h1n1+flu/" target="_blank">Interactive maps, quiz, FAQ, latest news and video</a><strong>HOW TO: </strong><a href="http://www.usatoday.com/news/health/2009-09-20-flu-guide_N.htm?csp=34" target="_blank">Get through flu season unscathed</a>Outbreaks Near Me, a new, free application developed by non-profit HealthMap, is among a slew of flu-themed applications available on the iTunes App Store for iPhone and iPod Touch owners.</p>
<p> A couple of dozen other flu-related apps have been created recently, including HMSMobile <a title="More news, photos about Swine Flu" href="http://content.usatoday.com/topics/topic/Health+and+Wellness/Diseases/Swine+flu" target="_blank">Swine Flu</a> Center, by Harvard Medical School, which offers medical advice with animations. Others include flu games and jokes such as Swine Scan, which supposedly scans your body to detect infection.</p>
<p> Outbreaks Near Me works like a GPS. It finds your location and tells you where H1N1 and other infectious outbreaks are occurring nearby with a display of pushpins on a map. Click on a pushpin and you can read news reports as well as personal accounts submitted by users. It also lets you set up an alert system, so if H1N1 arrives in your area, you&#8217;ll get a heads-up.</p>
<p> &#8221;Our app is all about giving people real-time alerts. We didn&#8217;t develop this to increase fear. It&#8217;s about helping people arm themselves,&#8221; says John Brownstein, an assistant professor of pediatrics at <a title="More news, photos about Children's Hospital Boston" href="http://content.usatoday.com/topics/topic/Organizations/Children's+Hospital+Boston" target="_blank">Children&#8217;s Hospital Boston</a> and Harvard Medical School, who developed the app with colleagues at <a title="More news, photos about Massachusetts Institute of Technology" href="http://content.usatoday.com/topics/topic/Organizations/Schools/Massachusetts+Institute+of+Technology" target="_blank">Massachusetts Institute of Technology</a>&#8216;s Media Lab.</p>
<p> H1N1, popularly known as swine flu, has infected an estimated 22 million Americans this year from April to October, according to the <a title="More news, photos about Centers for Disease Control and Prevention" href="http://content.usatoday.com/topics/topic/Organizations/Government+Bodies/Centers+for+Disease+Control+and+Prevention" target="_blank">Centers for Disease Control and Prevention</a>. The CDC has reported that the outbreak is linked to almost 4,000 deaths, including 540 children.</p>
<p> Since Outbreaks Near Me launched Sept. 1, about 100,000 people have downloaded it, Brownstein says. Though the app also reports recent E. coli, malaria and other outbreaks, H1N1 has by far been the most-searched disease, he says.</p>
<p> Brownstein says the app has received more than 2,000 submissions. &#8220;People take photos of themselves in bed sick, or e-mail in to say their school is closed, or that there&#8217;s a vaccine shortage in their area,&#8221; he says.</p>
<p> Outbreaks Near Me co-developer Clark Freifeld, a graduate student in media art and sciences at Massachusetts Institute of Technology, says developers are analyzing submissions now and say the information appears to correlate with CDC data. It suggests the iPhone may be a sensitive tool for monitoring early outbreak trends, Freifeld says.</p>
<p> For big-picture influenza news, most people probably get information the traditional way, from CDC reports, says influenza expert William Schaffner, chair of the department of preventive medicine at Vanderbilt Medical Center in Nashville. Apps may be best when you want more focused information, he says. &#8220;Like what is happening in grandma&#8217;s town, where you&#8217;re going for Thanksgiving.&#8221;</p>
<p> The CDC does not comment on products such as apps, spokeswoman <a title="More news, photos about Karen Hunter" href="http://content.usatoday.com/topics/topic/Karen+Hunter" target="_blank">Karen Hunter</a> says. Hunter says the agency is in the prototype stage of several new flu apps for iPhone and the Google Android, and they&#8217;re already using mobile text messaging (to sign up, text HEALTH to 87000) and a mobile website (<a href="http://m.cdc.gov/">http://m.cdc.gov</a>) to distribute flu updates to tens of thousands of subscribers.</p>
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		<title>5 Health Tests You May Not Need</title>
		<link>http://medcall.wordpress.com/2009/11/25/5-health-tests-you-may-not-need/</link>
		<comments>http://medcall.wordpress.com/2009/11/25/5-health-tests-you-may-not-need/#comments</comments>
		<pubDate>Wed, 25 Nov 2009 13:48:24 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[Public Health News]]></category>

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		<description><![CDATA[ADVERTISEMENT Knowledge is power, unless that knowledge comes with so much baggage that it becomes crippling. Such is the trouble with many cancer and health screening tests. Last week the U.S. Preventive Services Task Force unleashed a maelstrom with its recommendations that women need mammograms less frequently, with regular breast-cancer screening starting at age 50, [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=28&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
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<p>Knowledge is power, unless that knowledge comes with so much baggage that it becomes crippling. Such is the trouble with many cancer and health screening tests.</p>
<p>Last week the U.S. Preventive Services Task Force unleashed a maelstrom with its recommendations that women need mammograms less frequently, with regular breast-cancer screening starting at age 50, not 40, and only biennially, not yearly.</p>
<p>The Task Force said it was responding to data showing that routine mammograms starting at age 40, as long recommended, rarely save lives and more often result in a misdiagnosis — detection of a breast cancer that&#8217;s either benign or growing too slowly to be of worry. This, in turn, leads to unnecessary anxiety and debilitating treatment.</p>
<p>Not everyone agreed with the new recommendations, published on November 17 online in the Annals of Internal Medicine. The American Cancer Society, for now, is sticking to its recommendation of yearly mammograms for women starting at age 40.</p>
<p>Yet nearly all health experts will agree that the benefits of most health screening techniques are either exaggerated by the health community or misunderstood by the public. A few discounted ones are below.</p>
<p><strong>Five questionable tests</strong></p>
<p><strong>PSA testing</strong>: A PSA blood test looks for prostate-specific antigen, a protein produced by the prostate gland. High levels are associated with prostate cancer. The problem is that the association isn&#8217;t always correct, and when it is, the prostate cancer isn&#8217;t necessarily deadly. Nearly 20 percent of men will be diagnosed with prostate cancer, which sounds scary, but only about 3 percent of all men die from it. The PSA test usually leads to overdiagnosis — biopsies and treatment in which the side effects are impotence and incontinence.</p>
<p><strong>DEXA</strong>: Dual energy X-ray absorptiometry (DEXA or DXA) in a technique developed in the 1980s that measures, among many things, bone mineral density. The scans can determine bone strength and signs of osteopenia, a possible precursor to osteoporosis. Limitations abound, though. Measurements vary from scan to scan of the same person, as well as from machine to machine. DEXA doesn&#8217;t capture the collagen-to-mineral ratio, which is more predictive of bone strength than just mineral density. And higher bone mineral density doesn&#8217;t necessarily mean stronger bones, for someone with more bone mass will have more minerals but could have weaker bones.</p>
<p><strong>Full-body scans</strong>: If you got extra cash, usually more than $1,000, you may be tempted to get a full-body CT scan to find everything wrong with you. Avoid that temptation. For the most part, these are done so poorly by purely commercial enterprises that the results are useless. The scan will definitely find something abnormal that is likely of little concern. And it could very likely miss something that is a concern. For example, these scans aren&#8217;t done with special contrast agents to look for specific types of tumors or organ damage. You&#8217;re left only with a false sense of confidence. CT technology is excellent but only in the hands of an expert focused on a specific medical concern.</p>
<p><strong>Home menopause test</strong>: The home menopause test is almost in the realm of hokum, despite its popularity with a generation of women who grew up with the home pregnancy test. The test measures levels of FSH, or follicle-stimulating hormone, in the urine. Not only doesn&#8217;t the kit measure this well, FSH in the urine is a poor indicator of menopause status. Perhaps of little surprise is that FSH levels, like many female hormones, vary from day to day, particularly for pre-menopausal women. The home test kit may sound innocent enough, but some women might use this to assess whether they still need birth control.</p>
<p><strong>Home Alzheimer&#8217;s test</strong>: The home Alzheimer&#8217;s test is a scratch-and-sniff test, useful according to the manufacturers because a loss of smell can be an early signs of Alzheimer&#8217;s disease. There&#8217;s a little truth here. Anosmia, a loss of smell, has been associated with Alzheimer&#8217;s disease and Parkinson&#8217;s disease. But that association seems rare; most anosmics don&#8217;t have a degenerative brain disease. Your failure of the smell test is likely indicative of, well, a smelling problem. Yet while the home test verges on the naive, serious research continues on whether anosmia serves as some sort of canary in the coal mine for burgeoning neurological disorders.</p>
<p><strong>Two good tests</strong></p>
<p>Aside from self-examination for skin cancer, colon and cervical cancer screens are the only screens strongly recommended by most doctors.</p>
<p>Colonoscopies are very effective in finding and removing precancerous polyps. Colon cancer takes nearly a decade to develop, and starting a decadal colonoscopy routine at age 50 would significantly eliminate your risk for colon cancer. Similarly, Pap smears are highly effective identifying precancerous and malignant cervical cancer cells. Women should get a Pap smear at least every other year starting at age 20.</p>
<p>Health screenings aren&#8217;t entirely useless. They are essential, in fact, for people at high risk of developing a disease, such as women with a clear family history of breast cancer. Screening is simply imperfect, and the public needs to understand the benefits and limitations of each one.</p>
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		<title>China expert warns of pandemic flu mutation</title>
		<link>http://medcall.wordpress.com/2009/11/25/china-expert-warns-of-pandemic-flu-mutation/</link>
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		<pubDate>Wed, 25 Nov 2009 13:47:29 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[H1N1 Update]]></category>

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		<description><![CDATA[By Stefanie McIntyre HONG KONG (Reuters) &#8211; China must be alert to any mutation or changes in the behavior of the H1N1 swine flu virus because the far deadlier H5N1 bird flu virus is endemic in the country, a leading Chinese disease expert said. Zhong Nanshan, director of the Guangzhou Institute of Respiratory Diseases in [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=26&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>By Stefanie McIntyre</p>
<p>HONG KONG (Reuters) &#8211; China must be alert to any mutation or changes in the behavior of the H1N1 swine flu virus because the far deadlier H5N1 bird flu virus is endemic in the country, a leading Chinese disease expert said.</p>
<p>Zhong Nanshan, director of the Guangzhou Institute of Respiratory Diseases in China&#8217;s southern Guangdong province, said the presence of both viruses in China meant they could mix and become a monstrous hybrid &#8212; a bug packed with strong killing power that can transmit efficiently among people.</p>
<p>&#8220;China, as you know, is different from other countries. Inside China, H5N1 has been existing for some time, so if there is really a reassortment between H1N1 and H5N1, it will be a disaster,&#8221; Zhong said in an interview with Reuters Television.</p>
<p>&#8220;This is something we need to monitor, the change, the mutation of the virus. This is why reporting of the death rate must be really transparent.&#8221;</p>
<p>The World Health Organization warned on Tuesday that H5N1 had erupted in poultry in Egypt, Indonesia, Thailand and Vietnam, posing once again a threat to humans.</p>
<p>&#8220;First, it places those in direct contact with birds &#8212; usually rural folk and farm workers &#8212; at risk of catching the often-fatal disease. Second, the virus could undergo a process of &#8220;reassortment&#8221; with another influenza virus and produce a completely new strain,&#8221; it said.</p>
<p>&#8220;The most obvious risk is of H5N1 combining with the pandemic &#8230; (H1N1) virus, producing a flu virus that is as deadly as the former and as contagious as the latter.&#8221;</p>
<p>Zhong told the Chinese media last week that China may have had more H1N1 flu deaths than it has reported, with some local governments possibly concealing suspect cases.</p>
<p>The doctor is known for his candor and work in fighting Severe Acute Respiratory Syndrome in 2003, when nationwide panic and international alarm erupted after it emerged that officials hid or underplayed the spreading epidemic.</p>
<p>Cover-ups by local governments in 2003 during the SARS epidemic led to the sackings of several officials. More than 300 people died in that outbreak.</p>
<p>China, the world&#8217;s most populous country, has reported around 70,000 cases of H1N1 and 53 death from the virus.</p>
<p>While some regions simply lack the technology to test for H1N1, other areas have been treating deaths as cases of ordinary pneumonia without a question, Zhong said.</p>
<p>&#8220;Some local healthcare authorities are reluctant, unwilling to test patients with severe pneumonia because there&#8217;s some latent rule which says the more H1N1 deaths, the less effective the control and prevention work in your area,&#8221; Zhong said.</p>
<p>Zhong said China&#8217;s health minister Chen Zhu rang him up last week and agreed with his views. A notice then appeared on the ministry&#8217;s website threatening severe punishment for officials caught concealing deaths from H1N1 swine flu.</p>
<p>WHO reported more than 526,060 laboratory confirmed cases of H1N1 worldwide on November 15, with at least 6,770 deaths. However, it has stressed for months now that the figures were only the tip of the iceberg.</p>
<p>It urged countries to place more resources on mitigating the disease rather then on costly prevention measures or testing everyone. All WHO and the U.S. CDC will say is that &#8220;millions&#8221; have been infected.</p>
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		<title>Guidelines Push Back Age for Cervical Cancer Tests</title>
		<link>http://medcall.wordpress.com/2009/11/25/guidelines-push-back-age-for-cervical-cancer-tests/</link>
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		<pubDate>Wed, 25 Nov 2009 13:45:48 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[Cancer News]]></category>

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		<description><![CDATA[By DENISE GRADY New guidelines for cervical cancer screening say women should delay their first Pap test until age 21, and be screened less often than recommended in the past. The advice, from the American College of Obstetricians and Gynecologists, is meant to decrease unnecessary testing and potentially harmful treatment, particularly in teenagers and young [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=24&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>By <a title="More Articles by Denise Grady" href="http://topics.nytimes.com/top/reference/timestopics/people/g/denise_grady/index.html?inline=nyt-per">DENISE GRADY</a></p>
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<p>New guidelines for <a title="In-depth reference and news articles about Cervical Cancer." href="http://health.nytimes.com/health/guides/disease/cervical-cancer/overview.html?inline=nyt-classifier">cervical cancer</a> screening say women should delay their first Pap test until age 21, and be screened less often than recommended in the past.</p>
<p>The advice, from the American College of Obstetricians and Gynecologists, is meant to decrease unnecessary testing and potentially harmful treatment, particularly in teenagers and young women. The group’s previous guidelines had recommended yearly testing for young women, starting within three years of their first sexual intercourse, but no later than age 21.</p>
<p>Arriving on the heels of hotly disputed guidelines calling for less use of <a title="In-depth reference and news articles about Mammography." href="http://health.nytimes.com/health/guides/test/mammography/overview.html?inline=nyt-classifier">mammography</a>, the new recommendations might seem like part of a larger plan to slash <a title="In-depth reference and news articles about Cancer." href="http://health.nytimes.com/health/guides/disease/cancer/overview.html?inline=nyt-classifier">cancer</a> screening for women. But the timing was coincidental, said Dr. Cheryl B. Iglesia, the chairwoman of a panel in the obstetricians’ group that developed the <a title="In-depth reference and news articles about Pap smear and treatment." href="http://health.nytimes.com/health/guides/specialtopic/pap-smear-and-treatment/overview.html?inline=nyt-classifier">Pap smear</a> guidelines. The group updates its advice regularly based on new medical information, and Dr. Iglesia said the latest recommendations had been in the works for several years, “long before the Obama health plan came into existence.”</p>
<p>She called the timing crazy, uncanny and “an unfortunate perfect storm,” adding, “There’s no political agenda with regard to these recommendations.”</p>
<p>Dr. Iglesia said the argument for changing Pap screening was more compelling than that for cutting back on mammography — which the obstetricians’ group has staunchly opposed — because there is more potential for harm from the overuse of Pap tests. The reason is that young women are especially prone to develop abnormalities in the cervix that appear to be precancerous, but that will go away if left alone. But when Pap tests find the growths, doctors often remove them, with procedures that can injure the cervix and lead to problems later when a woman becomes pregnant, including premature birth and an increased risk of needing a Caesarean.</p>
<p>Still, the new recommendations for Pap tests are likely to feed a political debate in Washington over health care overhaul proposals. The mammogram advice led some Republicans to predict that such recommendations would lead to rationing.</p>
<p>Senator <a title="More articles about Tom Coburn." href="http://topics.nytimes.com/top/reference/timestopics/people/c/tom_coburn/index.html?inline=nyt-per">Tom Coburn</a>, a Republican from Oklahoma who is also a physician, said in an interview that he would continue to offer Pap smears to sexually active young women. Democratic proposals to involve the government more deeply in the nation’s health care system, he said, would lead the new mammography, Pap smear and other guidelines to be adopted without regard to patient differences, hurting many people.</p>
<p>“These are going to be set in stone,” Mr. Coburn said.</p>
<p>Senator <a title="More articles about Arlen Specter." href="http://topics.nytimes.com/top/reference/timestopics/people/s/arlen_specter/index.html?inline=nyt-per">Arlen Specter</a>, a Pennsylvania Democrat and longtime advocate for cancer screening, said in an interview: “And this Pap smear guideline is yet another cut back in screening? That is curious.” Mr. Specter, who was treated for <a title="In-depth reference and news articles about Hodgkin's Disease." href="http://health.nytimes.com/health/guides/disease/hodgkins-lymphoma/overview.html?inline=nyt-classifier">Hodgkin’s lymphoma</a> in 2005 and 2008, said Congress was committed to increasing cancer screenings, not limiting them.</p>
<p>Representative Rosa DeLauro, Democrat of Connecticut, said that the new guidelines would have no effect on federal policy and that “Republicans are using these new recommendations as a distraction.”</p>
<p>“Making such arguments, especially at this critical point in the debate, merely clouds the very simple issue that our health reform bill would increase access to care for millions of women across the country,” she said.</p>
<p>There are 11,270 new cases of cervical cancer and 4,070 deaths per year in the United States. One to 2 cases occur per 1,000,000 girls ages 15 to 19 — a low incidence that convinces many doctors that it is safe to wait until 21 to screen.</p>
<p>The doctors’ group also felt it was safe to test women less often because cervical cancer grows slowly, so there is time to catch precancerous growths. Cervical cancer is caused by a sexually transmitted virus, <a title="Recent and archival health news about human papilloma virus (hpv)." href="http://topics.nytimes.com/top/news/health/diseasesconditionsandhealthtopics/humanpapillomavirushpv/index.html?inline=nyt-classifier">human papillomavirus</a>, or HPV, that is practically ubiquitous. Only some people who are exposed to it develop cancer; in most, the immune system fights off the virus. If cancer does develop, it can take 10 to 20 years after exposure to the virus.</p>
<p>The new guidelines say women 30 and older who have three consecutive Pap tests that were normal, and who have no history of seriously abnormal findings, can stretch the interval between screenings to three years.</p>
<p>In addition, women who have a total <a title="In-depth reference and news articles about Hysterectomy." href="http://health.nytimes.com/health/guides/surgery/hysterectomy/overview.html?inline=nyt-classifier">hysterectomy</a> (which removes the uterus and cervix) for a noncancerous condition, and who had no severe abnormalities on previous Pap tests, can quit having the tests entirely.</p>
<p>The guidelines also say that women can stop having Pap tests between 65 and 70 if they have three or more negative tests in a row and no abnormal test results in the last 10 years.</p>
<p>The changes do not apply to women with certain health problems that could make them more prone to aggressive cervical cancer, including <a title="In-depth reference and news articles about AIDS/H.I.V.." href="http://health.nytimes.com/health/guides/disease/aids/overview.html?inline=nyt-classifier">H.I.V.</a> infection or having an organ transplant or other condition that would lead to a suppressed immune system.</p>
<p>It is by no means clear that doctors or patients will follow the new guidelines. Medical groups, including the <a title="More articles about American Cancer Society" href="http://topics.nytimes.com/top/reference/timestopics/organizations/a/american_cancer_society/index.html?inline=nyt-org">American Cancer Society</a>, have been suggesting for years that women with repeated normal Pap tests could begin to have the test less frequently, but many have gone on to have them year after year anyway.</p>
<p>Debbie Saslow, director of breast and gynecologic cancer for the American Cancer Society, said professional groups were particularly concerned because many teenagers and young women were being tested and then needlessly subjected to invasive procedures.</p>
<p>In addition, Dr. Saslow said, doctors in this country have been performing 15 million Pap tests a year to look for cervical cancer in women who have no cervix, because they have had hysterectomies.</p>
<p>Dr. Carol L. Brown, a gynecologic oncologist and surgeon at <a title="More articles about Memorial Sloan-Kettering Cancer Center" href="http://topics.nytimes.com/top/reference/timestopics/organizations/m/memorial_sloankettering_cancer_center/index.html?inline=nyt-org">Memorial Sloan-Kettering Cancer Center</a>, said the new guidelines should probably not be applied to all women, because there are some girls who begin having sex at 12 or 13 and may be prone to develop cervical cancer at an early age.</p>
<p>“I’m concerned that whenever you send a message out to the public to do less, the most vulnerable people at highest risk might take the message and not get screened at all,” Dr. Brown said.</p>
<p>Dr. Kevin M. Holcomb, an associate professor of clinical obstetrics and gynecology at <a title="More articles about New York-Presbyterian Hospital" href="http://topics.nytimes.com/top/reference/timestopics/organizations/n/new_york-presbyterian_hospital/index.html?inline=nyt-org">NewYork-Presbyterian/Weill Cornell</a> hospital, said that when he heard the advice to delay Pap testing until 21, “My emotional response is ‘Wow, that seems dangerous,’ and yet I know the chances of an adolescent getting cervical cancer are really low.”</p>
<p>As with the new mammogram recommendations, women may not readily give up a yearly cancer test.</p>
<p>“For people who’ve been having the testing regularly every year, it’s a big emotional change to test less frequently and there’s this fear of ‘Oh my gosh, I might be missing something,’ ” said Ivy Guetta, 49, of Westport, Conn., who plans to continue with annual Pap tests. Ms. Guetta has three daughters, ages 17, 14 and 8, and at the moment, she would not encourage them to wait until they turn 21.</p>
<p>Jen Jemison, 24, a legal assistant from Babylon, N.Y., said she thought she began getting Pap smears when she was about 18, but said that if she had been aware that the procedure for treating precancerous lesions could lead to premature births, she would have waited until she turned 21.</p>
<p>On the other hand, Ms. Jemison said that now that she is over 21, “I would still go every year” for the Pap test.</p>
<p>“One of my cousins had cervical cancer, so that’s in my head too,” she said. “I’d rather get it checked out regularly than have to worry about that.”</p>
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		<title>Swine flu outbreak stirs panic, political discord in Ukraine</title>
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		<pubDate>Wed, 25 Nov 2009 13:43:40 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[H1N1 Update]]></category>

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		<description><![CDATA[By Philip P. Pan, Washington Post  &#124;  November 22, 2009 KIEV &#8211; One night at the height of the panic over what people here call the California flu, as 24-hour news stations tracked a rising death toll and politicians speculated about a mystery lung plague, Ukraine’s prime minister rushed to the airport to greet a [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=22&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>By Philip P. Pan, Washington Post  |  November 22, 2009</p>
<p>KIEV &#8211; One night at the height of the panic over what people here call the California flu, as 24-hour news stations tracked a rising death toll and politicians speculated about a mystery lung plague, Ukraine’s prime minister rushed to the airport to greet a shipment of Tamiflu as if it were a foreign dignitary.</p>
<p>Not to be outdone, the president, a bitter political foe, dispatched a top aide to meet the plane, too.</p>
<p>In neighboring Belarus, the government took an opposite tack, accusing drug companies of fanning hysteria over swine flu to boost profit. In Poland, the health minister is under fire for refusing to stock up on a vaccine, while doctors in Hungary are resisting orders to administer the shot. In Turkmenistan, the authorities have been accused of covering up an epidemic, with infectious-disease wards reportedly full and people being turned away.</p>
<p>As the pandemic H1N1 influenza surges with the onset of winter, the nations of Eastern Europe and the former Soviet Union appear particularly vulnerable to the deadly virus. Burdened with weak health care systems, relatively inexperienced news media outlets, and shaky governments that have little public trust, the region also seems ripe for panic and political strife over the flu.</p>
<p>The potential for trouble is already on display in Ukraine, where 1.5 million of its 46 million people have had diagnoses of flu and respiratory illnesses since the start of the outbreak and 356 have died, according to the government. The World Health Organization suspects that most of the cases are swine flu, making Ukraine among the hardest-hit countries in Europe, including Russia, Bulgaria, Moldova, and Poland.</p>
<p>More telling than the numbers, however, has been the widespread fear the virus has caused in Ukraine, and the outsize impact it has had on the nation’s political landscape.</p>
<p>In the weeks since Prime Minister Yulia Tymoshenko announced measures against the spread of the flu &#8211; shutting the nation’s schools and banning public gatherings &#8211; anxious residents have overwhelmed hospitals and pharmacies, buying up supplies of medicine, gauze masks, and home remedies such as lemons and garlic. Rumors have proliferated that people are dying of a new, more lethal strain of the virus.</p>
<p>Semyon Gluzman, a psychiatrist and Soviet-era dissident in Kiev, said the fear was a rational response in a nation with a dysfunctional health care system and a corrupt, ineffective government.</p>
<p>Ukraine’s news media &#8211; which gained new freedoms after the Orange Revolution &#8211; have provided round-the-clock, often sensational coverage of the outbreak. The nation’s leading politicians are jockeying for advantage ahead of the January presidential election, accusing one another of exploiting the crisis by doing too much or endangering lives by doing too little.</p>
<p>President Viktor Yushchenko, running far behind in his reelection bid, accused the prime minister of failing to prepare for the outbreak, saying that she left the national flu center staffed with only one employee, put doctors in danger, and allowed the H1N1 virus to mutate into a “more aggressive’’ strain. Aides floated the idea of postponing the election because of the outbreak.</p>
<p>Tymoshenko, who was a Yushchenko ally in the Orange Revolution, fought back, criticizing him for blocking $125 million in emergency spending to fight the flu and saying he would be “responsible for every person who is ill today or dies.’’ <img src="http://cache.boston.com/bonzai-fba/File-Based_Image_Resource/dingbat_story_end_icon.gif" border="0" alt="" width="6" height="8" /></p>
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		<title>Professors file health care lawsuit</title>
		<link>http://medcall.wordpress.com/2009/11/25/professors-file-health-care-lawsuit/</link>
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		<pubDate>Wed, 25 Nov 2009 13:43:00 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[Public Health News]]></category>

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		<description><![CDATA[Adjunct instructors challenge denial of insurance coverage By Tracy Jan, Globe Staff  &#124;  November 24, 2009 A group of part-time community college instructors filed a lawsuit yesterday against the state, saying that hundreds of adjunct faculty in Massachusetts’ public higher education system are unfairly denied health care coverage. The lawsuit, filed in Suffolk Superior Court [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=19&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<h2>Adjunct instructors challenge denial of insurance coverage</h2>
<p>By Tracy Jan, Globe Staff  |  November 24, 2009</p>
<p>A group of part-time community college instructors filed a lawsuit yesterday against the state, saying that hundreds of adjunct faculty in Massachusetts’ public higher education system are unfairly denied health care coverage.</p>
<p>The lawsuit, filed in Suffolk Superior Court on behalf of five instructors, follows nearly a decade of unsuccessful wrangling with state legislators to get an adjunct health insurance bill enacted into law. It also comes as schools, particularly community colleges, are increasingly turning to adjuncts amid burgeoning enrollment.</p>
<p>“We’ve been trying on the Hill to persuade the state to do the right thing, and, to be frank, I just ran out of patience,’’ said Joseph T. LeBlanc, president of the Massachusetts Community College Council, which is a plaintiff in the suit, along with the Massachusetts Teachers Association. “It’s a case of justice. The state ought to be providing a large chunk of these people with a health insurance plan.’’</p>
<p>The situation is particularly startling, the plaintiffs say, given the 2006 state law mandating health insurance coverage for all residents. The Teachers Association estimates that about 500 adjunct faculty members meet the state’s longtime definition of part-time employees &#8211; those who working at least 18.75 hours a week &#8211; and should be eligible for state health insurance because they work at least that amount, including classroom, grading, and preparation time.</p>
<p>If successful, the lawsuit would set a legal precedent that would extend to adjunct faculty at all the state colleges and universities, said Matthew Jones, attorney for the Massachusetts Teachers Association.</p>
<p>Extending coverage to adjunct faculty at community colleges alone could cost upwards of $2 million a year as the state is struggling to make ends meet. Officials of the Department of Higher Education and the state’s Group Insurance Commission, who are among the parties named in the lawsuit, declined to comment on the lawsuit yesterday.</p>
<p>As colleges scramble to meet rising enrollment by hiring cheaper, part-time faculty, the adjunct ranks have expanded to about 4,300 instructors in the state’s 15 community college campuses, a 13 percent increase from six years ago.</p>
<p>More than half of undergraduate courses at community colleges across the state are taught by part-time instructors, who make up two-thirds of community college faculty, according to the Massachusetts Community College Council.</p>
<p>“We’re the best deal going for the schools,’’ said Patrick Lochelt, a plaintiff and an English instructor who teaches eight classes a semester at Northern Essex Community College in Haverhill, Middlesex Community College in Lowell, and the University of Massachusetts at Lowell. “In some ways, it really is exploitation.’’</p>
<p>Lochelt’s class load, with nearly 200 students per semester, is nearly twice as much as a full-time instructor, but he is paid far less, about $2,700 per course. He said he spends 23 hours a week in class and an additional 15 hours a week grading papers. He also serves as the faculty adviser for the award-winning student literary magazine at Northern Essex, an unpaid position.</p>
<p>Many adjunct professors, like Lochelt, patch together a full-time living teaching multiple courses at several colleges and shell out hundreds of dollars each month for private health insurance.</p>
<p>“Luckily, I’m only 30 and don’t have any health issues, but if I did, I’d be in big trouble,’’ Lochelt said.</p>
<p>But as insurance rates skyrocket, some instructors say, they can no longer afford the premiums.</p>
<p>Cynthia Duda, another plaintiff and an English instructor who teaches six classes at North Shore Community College and Bunker Hill Community College, said she recently switched from a $910 a month health plan to a bare-bones $638 a month plan that does not cover urgent care.</p>
<p>“At my age, I need all the insurance I can get,’’ said Duda, 61. “I am killing myself teaching all these courses trying to scrape up this health insurance money, trying to make it to Medicare. This is not right.’’</p>
<p>When Duda fell ill on a recent weekend and lost her voice, she said, she avoided going to the doctor because she could not afford to do so.</p>
<p>“I just had to take a chance that it wasn’t something serious,’’ Duda said.</p>
<p>In comparison, full-time community college instructors who are covered by the state’s plans for individuals pay between $80 and $220 a month for health insurance, or about 20 percent to 25 percent of the cost.</p>
<p>Duda estimates that even as a part-time instructor, she works about 40 hours a week in and out of the classroom.</p>
<p>She said that since 1990, she has taught a full schedule, including summers, nights, and weekends, though she is still considered a temporary contract worker.</p>
<p>“I’m working full time for the state of Massachusetts, the only state with so-called universal health care,’’ Duda said. “Great, where’s mine? In the end, it takes a toll on you inside. That’s when I think, why don’t I matter? It’s scary.’’</p>
<p>Amy Whitcomb Slemmer &#8211; executive director of Health Care For All, a consumer advocate group &#8211; said health care is “a basic human right.’’</p>
<p>“To deny it to educators, whom we entrust to cultivate and enrich the state’s young minds, seems unkind and unfair,’’ said Slemmer.</p>
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		<title>Lung bypass helps some H1N1 victims</title>
		<link>http://medcall.wordpress.com/2009/11/25/lung-bypass-helps-some-h1n1-victims/</link>
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		<pubDate>Wed, 25 Nov 2009 13:41:29 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[H1N1 Update]]></category>

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		<description><![CDATA[By Associated Press  &#124;  November 24, 2009 WASHINGTON &#8211; A technology originally developed for premature babies might be helping to save some of the sickest swine flu patients by rerouting their blood so their lungs can rest. It’s a risky approach using equipment that only certain specialized hospitals have. But faced with children and young [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=16&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>By Associated Press  |  November 24, 2009</p>
<p>WASHINGTON &#8211; A technology originally developed for premature babies might be helping to save some of the sickest swine flu patients by rerouting their blood so their lungs can rest.</p>
<p>It’s a risky approach using equipment that only certain specialized hospitals have. But faced with children and young adults struggling to breathe despite ventilators, intensive-care doctors are dusting off these machines, named ECMO for extracorporeal membrane oxygenation.</p>
<p>“It was pretty scary knowing that was his blood flowing through those tubes in and out of his body,’’ said Susie Damm of Omaha, whose 19-year-old son, Ryan, survived a life-threatening bout after 10 days on ECMO.</p>
<p>No one knows which patients are most likely to benefit &#8211; not everyone does. But ECMO is gaining attention after Australian researchers reported that the machines helped during that country’s outbreak. A voluntary US-based registry counts 107 critically ill swine flu patients recently treated with ECMO, most from this country.</p>
<p>Estimates from the federal Centers for Disease Control and Prevention suggest that swine flu has hospitalized 98,000 Americans in the past six months, and killed nearly 4,000. <img src="http://cache.boston.com/bonzai-fba/File-Based_Image_Resource/dingbat_story_end_icon.gif" border="0" alt="" width="6" height="8" /></p>
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		<title>Hope (and skepticism) as man’s 23-year coma ends</title>
		<link>http://medcall.wordpress.com/2009/11/25/hope-and-skepticism-as-man%e2%80%99s-23-year-coma-ends/</link>
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		<pubDate>Wed, 25 Nov 2009 13:40:49 +0000</pubDate>
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				<category><![CDATA[Public Health News]]></category>

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		<description><![CDATA[In typed message, tells of loneliness and frustration By Raf Casert, Associated Press  &#124;  November 25, 2009 BRUSSELS &#8211; With a caretaker holding his hand, a Belgian man who was diagnosed as comatose for 23 years typed out a message yesterday that he felt reborn after decades of loneliness and frustration. A leading bioethicist, however, [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=14&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<h2>In typed message, tells of loneliness and frustration</h2>
<p>By Raf Casert, Associated Press  |  November 25, 2009</p>
<p><strong></strong>BRUSSELS &#8211; With a caretaker holding his hand, a Belgian man who was diagnosed as comatose for 23 years typed out a message yesterday that he felt reborn after decades of loneliness and frustration.</p>
<p>A leading bioethicist, however, expressed skepticism that the man was truly communicating on his own.</p>
<p>Car-crash victim Rom Houben was diagnosed as being in a vegetative state but appears to have been conscious the whole time, doctors here said.</p>
<p>An expert using a specialized type of brain scan that was not available in the 1980s says he finally realized Houben was conscious and provided him with the equipment to communicate.</p>
<p>Assisted by a speech therapist who rapidly moved his finger letter by letter along a touch-screen keyboard, Houben told AP Television News that years of being unable to move or communicate left him feeling “alone, lonely, frustrated, but also blessed with my family.’’</p>
<p>The therapist, Linda Wouters, told APTN that she can feel Houben guiding her hand with gentle pressure from his fingers, and that she feels him objecting when she moves his hand toward an incorrect letter.</p>
<p>“It was especially frustrating when my family needed me. I could not share in their sorrow. We could not give each other support,’’ Houben wrote during the interview at the ‘t Weyerke institute in eastern Belgium.</p>
<p>“Just imagine. You hear, see, feel, and think but no one can see that. You undergo things. You cannot participate in life.’’</p>
<p>Arthur Caplan, a bioethics professor at the University of Pennsylvania, said he is skeptical of Houben’s ability to communicate after seeing video of his hand being moved along the keyboard.</p>
<p>“That’s called ‘facilitated communication,’ ’’ Caplan said. “That is ouija board stuff. It’s been discredited time and time again. When people look at it, it’s usually the person doing the pointing who’s doing the messages, not the person they claim they are helping.’’</p>
<p>Caplan also said that the statements Houben allegedly made with the computer strike him as unnatural for someone with such a profound injury and an inability to communicate for decades.</p>
<p>Asked how he felt when his consciousness was discovered, Houben responded through the aide that: “I especially felt relief. Finally be able to show that I was indeed there.’’</p>
<p>“Just like with a baby, it happens with a lot of stumbling,’’ he wrote.</p>
<p>The doctor who discovered that Houben had been wrongly diagnosed said that he is re-examining dozens of other cases.</p>
<p>Dr. Steven Laureys said he has discovered some degree of consciousness using state-of-the-art equipment in other patients but won’t say how many. He looks at about 50 cases from around the world a year but none are as extreme as that of Rom Houben, who was fully conscious inside a paralyzed body. Many center on the fine distinction between a vegetative state and minimal consciousness.</p>
<p>He said yesterday that: “It is very difficult to tell the difference.’’</p>
<p>His studies showed that some 40 percent of patients with consciousness disorders are wrongly given a diagnosis of a vegetative state.</p>
<p>“It is clearly unacceptable. It is four times out of ten 10 that they think the patient is in a vegetative state but in reality he is minimally conscious,’’ Laureys said. <img src="http://cache.boston.com/bonzai-fba/File-Based_Image_Resource/dingbat_story_end_icon.gif" border="0" alt="" width="6" height="8" /></p>
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		<title>Shades of gray</title>
		<link>http://medcall.wordpress.com/2009/11/25/shades-of-gray/</link>
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		<pubDate>Wed, 25 Nov 2009 13:38:51 +0000</pubDate>
		<dc:creator>medcall</dc:creator>
				<category><![CDATA[Cancer News]]></category>

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		<description><![CDATA[Can screening with CT scans save the lives of those at risk of lung cancer? Some say yes, but others say scans might hurt, not help. By Liz Kowalczyk, Globe Staff  &#124;  November 9, 2009 For the 42 percent of Americans who smoke cigarettes or once did, a ruling from the state’s highest court last [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=medcall.wordpress.com&amp;blog=10671292&amp;post=12&amp;subd=medcall&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<h2>Can screening with CT scans save the lives of those at risk of lung cancer? Some say yes, but others say scans might hurt, not help.</h2>
<p>By Liz Kowalczyk, Globe Staff  |  November 9, 2009</p>
<p>For the 42 percent of Americans who smoke cigarettes or once did, a ruling from the state’s highest court last month seemed to offer hope that a simple screening tool could help them ward off advanced lung cancer.</p>
<p>The judges decided that Philip Morris USA <strong></strong>may have to pay for lung scans for smokers so they can get early warning if they’ve developed cancer &#8211; and get treatment before it spreads into a deadly mass. (A federal court would have to affirm the state’s decision before the company would have to pay.)</p>
<p>Even before the court weighed in, advocates had been pressing politicians for money to pay for CT scans for high-risk but asymptomatic people &#8211; insurers generally don’t cover the test for screening &#8211; particularly since a group of New York researchers published results in 2006 suggesting that screening is saving the lives of smokers, former smokers, and people exposed to secondhand smoke and other hazards, such as asbestos. Some smokers are so convinced of the benefits of CTs they pay the $400 screening fee themselves.</p>
<p>“Our movement is really taking hold,’’ said Joanne O’Connor, cochair of the Lung Cancer Alliance in Massachusetts, which is lobbying legislators for funding. “I wouldn’t want to find out [I had lung cancer] like my sister did when she was already stage four. She died six months later.’’</p>
<p>But even as pressure for CT scanning builds, many of the country’s top cancer specialists are saying not so fast. While advocating early detection may seem like a no-brainer, they dispute the 2006 study and argue that there is no evidence that screeningscans actually save lives. Even worse, they say scanning can be inaccurate and end up harming patients by exposing them to unnecessary procedures and surgery, which carry their own risks.</p>
<p>In fact, the federal government and most major health organizations, including the American Cancer Society and the American Lung Association, recommend against CT screening exams for lung cancer for both smokers and former smokers, calling into question the wisdom of the state court’s ruling.</p>
<p>“There’s an emotional appeal [to CT scanning]; there are people who are dying and you want to help them,’’ said Dr. Steven Woloshin, a professor at Dartmouth Medical School. “But we’ve been fooled again and again in medicine. Right now the only way to make a rational decision is to look at evidence.’’</p>
<p>The debate over CT scanning is of intense personal importance to smokers and former smokers &#8211; 96.5 million Americans &#8211; and to the thousands of people who get lung cancer each year but who never smoked. Lung cancer is among the most deadly cancers, because it is most often detected after it has metastasized, or spread, leading to a dismal 5-year death rate of 85 percent. The hope is that early detection will improve these terrible odds, just as mammography has decreased mortality for women with breast cancer by alerting them to the need for treatment earlier in the illness. Two large national studies may finally provide definitive answers as soon as next year.</p>
<p>Lynne Petty, 44, of Newburyport, said that as a former smoker she would “absolutely want’’ CT screening if it were covered by her insurance plan. It’s not just the cost that’s kept her from having the test, however, it’s that scanning is not part of mainstream medicine; she would not know how often to get screened or what to expect.</p>
<p>“CT scanning should become as commonplace as a mammogram and colonoscopy where people discuss it like they’re going to dentist’s office,’’ she said. “Did you have your lung scan this year?’’</p>
<p>The search for effective early detection for lung cancer dates to the 1960s. Since then, three randomized trials of lung cancer screening comparing X-rays with regular care found no difference in mortality between the two groups. Contrary to what one would expect, two of the trials actually reported small increases in death rates among patients who were screened; they had more lung cancer surgery, which carries a significant risk of death.</p>
<p>The search for a screening tool was revived in the 1990s with the widespread arrival of CT scans, which are more sensitive than X-rays.</p>
<p>The leading proponents of screening are a group of radiologists from New York Presbyterian Hospital-Weill Medical College of Cornell University, who published a hopeful but controversial study in the New England Journal of Medicine three years ago. Led by Dr. Claudia Henschke, researchers screened 31,567 asymptomatic people at risk for lung cancer using CT scans between 1993 and 2005. They found lung cancer in 484 participants, most of whom had stage 1 cancer. Their estimated 10-year survival rate was 80 percent &#8211; an unheard of success rate for people diagnosed with lung cancer.</p>
<p>“I have no doubt we are saving lives,’’ said Dr. Albert Miller, a professor at New York Medical College, and an investigator in the study.</p>
<p>The Massachusetts Supreme Court relied in part on Miller’s expert testimony during the lawsuit brought against Philip Morris by two Massachusetts smokers. Since the 2006 study was published, however, the New England Journal has published three corrections, including one from Henschke revealing that some of the funding for the study came from cigarette-maker Liggett Tobacco.</p>
<p>Dr. Barnett Kramer, associate director for disease prevention at the National Institutes of Health, said the study was faulty, partly because it did not compare patients who were screened to a control group. Kramer, who along with Woloshin, coauthored a rebuttal to Henschke’s study two years ago in the Archives in Internal Medicine, said that screening always will make it appear that people survived longer than those who were not screened.</p>
<p>They put it this way: Imagine a group of patients diagnosed with lung cancer at age 67 who all die at age 70. Their 10-year survival rate is 0 percent. If that same group of patients is diagnosed earlier by CT, at age 59, and they still all die at age 70, their 10-year survival rate is 100 percent. But no matter when they were diagnosed, they still died at the same age.</p>
<p>Annual screening, added Kramer, is always better at picking up slow growing cancers, because aggressive cancers make themselves known with symptoms, so the patients whose cancer was discovered by a CT scan probably would have done better anyway. And they may have cancers that would never become fatal.</p>
<p>“You’re treating and curing people who didn’t need to be treated and cured in the first place,’’ he said, and exposing those people to harm from pneumonia or other risks of surgery.</p>
<p>For now, he said, the best way to lower one’s risk of advanced lung cancer is to stop smoking and not resume &#8211; and to stay tuned for the results of the National Lung Screening Trial and the Prostate, Lung, Colorectal &amp; Ovarian Cancer Screening Trial, both sponsored by the National Cancer Institute.</p>
<p>These trials will compare lung cancer death rates for people screened annually with CT scans to those not screened and to those screened with a chest X-ray. “If the trials show that [CT scanning] works that would be wonderful, but they may not,’’ Woloshin said.</p>
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